Off‐target inhibition by active site‐targeting SHP 2 inhibitors
نویسندگان
چکیده
منابع مشابه
Inhibition of SHP-2 promotes radiosensitivity in glioma.
As a phosphatase, SHP-2 has been identified to be involved in regulating several cell functions, including growth, division, adhesion and motility. Therefore, SHP‑2 may affect the response of glioma to radiotherapy, such as via enhancing angiogenesis. The present study aimed to investigate the function of SHP‑2, a protein tyrosine phosphatase, in the radiosensitivity of glioma. U251, U87 and SH...
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*Graduate Program in Immunology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021; ¶Arthritis and Tissue Degeneration Program and Department of Medicine, Hospital for Special Surgery, New York, NY 10021; Laboratories of †Molecular Cell Biology and §Lymphocyte Signaling, The Rockefeller University, New York, NY 10021; and ‡Cancer Biology Program, Department of ...
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ژورنال
عنوان ژورنال: FEBS Open Bio
سال: 2018
ISSN: 2211-5463,2211-5463
DOI: 10.1002/2211-5463.12493